![]() Human narcolepsy characterized by excessive daytime sleepiness, cataplexy (ie emotionally-elicited sudden loss of muscle tone that often leads to collapse) and other. Relatively rare prevalence in dogs not known (human narcolepsy affects 0.02 to 0.18 of general population). : Mutation in the hypocretin (orexin) receptor 2 gene causes canine narcolepsy Journal of Neurology 246:985-986, 1999. Chronic sleep disorder that affects dogs and humans. The genetic test can clearly reveal the genotype of the animal and is a useful tool for breeders to prevent unintentional breeding of affected puppies. In the case of a mating between two heterozygous individuals, theoretically 25% of the offspring will be completely healthy, 50% of the offspring will be carriers and 25% of the offspring will inherit the mutated gene from both parents and will therefore be affected by the disease. Carriers of the mutated gene are clinically healthy but pass the mutation on to their offspring. This means that only individuals who inherit the mutated gene from both parents will develop the disease. The mode of inheritance of the mutation is autosomal recessive. These receptors are thus a key element in the regulation of sleep and wakefulness. In normal dogs, hypocretin activity is enhanced by a positive feedback mechanism mediated by hypocretin-2 receptors. 73 Narcolepsy/cataplexy has been reported in a young dog with distemper encephalitis.77 We have documented narcoleptic/cataplectic attacks in dogs with. The disease in Labrador retrievers is caused by mutation c.1105+5G>A in the HCRTR2 gene, which encodes the receptor for hypocretin-2. If the collapse lasts more than a few minutes, the dog may fall asleep during the episode. During the episodes of collapse the dog remains conscious, has its eyes open and is able to track objects with its eyes. The muscle weakness lasts for a few seconds to minutes. ![]() The first signs of cataplexy are a buckling of both hind legs and a drooping of neck. Cataplectic episodes occur usually in response to a positive emotional stimulus (food, play). Affected dogs are sleepy, unable to stay awake for extended periods of time and fall asleep faster than normal dogs. Affected dogss are sleepy, and cannot maintain long. Narcolepsy is a sleeping disorder characterised by shortened sleep latency and cataplexy (sudden temporary loss of muscle tone without loss of consciousness). Clinical features: Dogs with familial narcolepsy may show signs between 4 weeks to 6 months of age.
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